Ahmed Ameena T, Karter Andrew J, Warton E Margaret, Doan Jennifer U, Weisner Constance M
Kaiser Permanente Division of Research, Oakland, CA 94612, USA.
J Gen Intern Med. 2008 Mar;23(3):275-82. doi: 10.1007/s11606-007-0502-z. Epub 2008 Jan 8.
Alcohol consumption is a common behavior. Little is known about the relationship between alcohol consumption and glycemic control among people with diabetes.
To evaluate the association between alcohol consumption and glycemic control.
Survey follow-up study, 1994-1997, among Kaiser Permanente Northern California members.
38,564 adult diabetes patients.
Self-reported alcohol consumption, and hemoglobin A1C (A1C), assessed within 1 year of survey date. Linear regression of A1C by alcohol consumption was performed, adjusted for sociodemographic variables, clinical variables, and diabetes disease severity. Least squares means estimates were derived.
In multivariate-adjusted models, A1C values were 8.88 (lifetime abstainers), 8.79 (former drinkers), 8.90 (<0.1 drink/day), 8.71 (0.1-0.9 drink/day), 8.51 (1-1.9 drinks/day), 8.39 (2-2.9 drinks/day), and 8.47 (>/=3 drinks/day). Alcohol consumption was linearly (p < 0.001) and inversely (p = 0.001) associated with A1C among diabetes patients.
Alcohol consumption is inversely associated with glycemic control among diabetes patients. This supports current clinical guidelines for moderate levels of alcohol consumption among diabetes patients. As glycemic control affects incidence of complications of diabetes, the lower A1C levels associated with moderate alcohol consumption may translate into lower risk for complications.
饮酒是一种常见行为。对于糖尿病患者中饮酒与血糖控制之间的关系,人们了解甚少。
评估饮酒与血糖控制之间的关联。
1994 - 1997年对北加利福尼亚州凯撒医疗集团成员进行的调查随访研究。
38564名成年糖尿病患者。
自我报告的饮酒情况,以及在调查日期1年内评估的糖化血红蛋白(A1C)。对饮酒量与A1C进行线性回归分析,并对社会人口统计学变量、临床变量和糖尿病疾病严重程度进行校正。得出最小二乘均值估计值。
在多变量校正模型中,A1C值分别为8.88(终生戒酒者)、8.79(既往饮酒者)、8.90(每天饮酒量<0.1杯)、8.71(每天饮酒量0.1 - 0.9杯)、8.51(每天饮酒量1 - 1.9杯)、8.39(每天饮酒量2 - 2.9杯)和8.47(每天饮酒量≥3杯)。糖尿病患者中,饮酒量与A1C呈线性相关(p < 0.001)且呈负相关(p = 0.001)。
糖尿病患者中饮酒与血糖控制呈负相关。这支持了当前关于糖尿病患者适度饮酒的临床指南。由于血糖控制会影响糖尿病并发症的发生率,与适度饮酒相关的较低A1C水平可能意味着并发症风险降低。