Kölbel Tilo, Strandberg Karin, Donath Tobias, Mattiasson Ingrid, Stenflo Johan, Lindblad Bengt
Department of Vascular Diseases, Malmö University Hospital, Sweden.
Vasc Endovascular Surg. 2008 Apr-May;42(2):135-40. doi: 10.1177/1538574407311108. Epub 2008 Jan 9.
Increased thrombin activation was documented in patients with abdominal aortic aneurysm (AAA). Activated protein C-protein C inhibitor (APC-PCI) complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA and a control group, and the association between aneurysm size, growth rate, and APC-PCI was studied. The patients were divided into cohorts according to AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA cohorts (n = 232; median, 0.36 microg/L; 10th to 90th percentile, 0.18-1.01) compared with the control group (n = 41; median, 0.19 microg/L; 10th to 90th percentile, 0.11-0.31; P < or = .001). APC-PCI correlated with AAA diameter (r = .22; P = .001), body mass index (r = -.19; P = .004), and age (r = .19; P = .004). APC-PCI did not correlate with AAA growth rate (r = .11; P = .14).
腹主动脉瘤（AAA）患者存在凝血酶激活增加的情况。在232例AAA患者及一个对照组人群中检测了凝血酶生成的一种新生物标志物——活化蛋白C-蛋白C抑制剂（APC-PCI）复合物，并研究了动脉瘤大小、生长速率与APC-PCI之间的关联。根据AAA直径将患者分为不同队列，并与对照组进行比较。与对照组（n = 41；中位数，0.19μg/L；第10至90百分位数，0.11 - 0.31；P≤0.001）相比，所有AAA队列（n = 232；中位数，0.36μg/L；第10至90百分位数，0.18 - 1.01）中的APC-PCI显著更高。APC-PCI与AAA直径（r = 0.22；P = 0.001）、体重指数（r = -0.19；P = 0.004）及年龄（r = 0.19；P = 0.004）相关。APC-PCI与AAA生长速率不相关（r = 0.11；P = 0.14）。
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