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微小RNA与腹主动脉瘤发病机制的当前概念

MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm.

作者信息

Joviliano Edwaldo Edner, Ribeiro Mauricio Serra, Tenorio Emanuel Junior Ramos

机构信息

Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.

出版信息

Braz J Cardiovasc Surg. 2017 May-Jun;32(3):215-224. doi: 10.21470/1678-9741-2016-0050.

DOI:10.21470/1678-9741-2016-0050
PMID:28832801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5570395/
Abstract

Abdominal aortic aneurysm is an important cause of morbidity and mortality in the elderly. Currently, the only way to prevent rupture and death related to abdominal aortic aneurysms is through surgical intervention. Endovascular treatment is associated with less morbidity than conventional treatment. The formation of an aneurysm is a complex multifactorial process, involving destructive remodeling of the connective tissue around the affected segment of the aorta wall. MicroRNAs are small sequences of non-coding RNAs that control diverse cellular functions by promoting degradation or inhibition of translation of specific mRNAs. A profile aberrant expression of miRNAs has been linked to human diseases, including cardiovascular dysfunction.

摘要

腹主动脉瘤是老年人发病和死亡的重要原因。目前，预防与腹主动脉瘤相关的破裂和死亡的唯一方法是通过手术干预。与传统治疗相比，血管内治疗的发病率较低。动脉瘤的形成是一个复杂的多因素过程，涉及主动脉壁受影响节段周围结缔组织的破坏性重塑。微小RNA是非编码RNA的小序列，通过促进特定mRNA的降解或抑制其翻译来控制多种细胞功能。微小RNA的异常表达谱与包括心血管功能障碍在内的人类疾病有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b7/5570395/cced3793efd7/rbccv-32-03-0215-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b7/5570395/de1490ddcfa2/rbccv-32-03-0215-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b7/5570395/5bddc201e693/rbccv-32-03-0215-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b7/5570395/cced3793efd7/rbccv-32-03-0215-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b7/5570395/de1490ddcfa2/rbccv-32-03-0215-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b7/5570395/5bddc201e693/rbccv-32-03-0215-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b7/5570395/cced3793efd7/rbccv-32-03-0215-g03.jpg

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1
MicroRNAs and aneurysm formation.微小 RNA 与动脉瘤形成。
Trends Cardiovasc Med. 2011 Aug;21(6):172-7. doi: 10.1016/j.tcm.2012.05.005.
2
Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development.抑制 microRNA-29b 可减少小鼠腹主动脉瘤的发展。
J Clin Invest. 2012 Feb;122(2):497-506. doi: 10.1172/JCI61598. Epub 2012 Jan 24.
3
miR-29b participates in early aneurysm development in Marfan syndrome.miR-29b 参与马凡综合征早期动脉瘤的形成。
一种治疗动脉瘤的新策略：通过将 TIMP-1 编码的合成 mRNA 递送至动脉来抑制 MMP-9 活性。
Int J Mol Sci. 2024 Jun 15;25(12):6599. doi: 10.3390/ijms25126599.
4
The effects of statin therapy on aneurysm size, growth rate, and matrix metalloproteinases-9 levels in patients with aortic aneurysm: a systematic review and meta-analysis.他汀类药物治疗对主动脉瘤患者动脉瘤大小、生长速率及基质金属蛋白酶-9水平的影响：一项系统评价与荟萃分析
Egypt Heart J. 2023 Oct 13;75(1):88. doi: 10.1186/s43044-023-00407-9.
5
Intracranial Aneurysms Induced by Through Regulation of in Patients With Hypertension-An Integrated Analysis Based on Multiple Datasets and Algorithms.高血压患者中通过调控……诱导的颅内动脉瘤——基于多数据集和算法的综合分析 （原文中“Through Regulation of ”后面内容缺失）
Front Neurol. 2022 May 17;13:877801. doi: 10.3389/fneur.2022.877801. eCollection 2022.
6
Epidemiological Evidence Between Variants in Matrix Metalloproteinases-2, -7, and -9 and Cancer Risk.基质金属蛋白酶-2、-7和-9的变体与癌症风险之间的流行病学证据
Front Oncol. 2022 Apr 28;12:856831. doi: 10.3389/fonc.2022.856831. eCollection 2022.
7
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In Vivo. 2022 May-Jun;36(3):1120-1125. doi: 10.21873/invivo.12810.
8
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9
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Int J Mol Med. 2021 May;47(5). doi: 10.3892/ijmm.2021.4923. Epub 2021 Mar 31.
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4
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J Vasc Surg. 2011 May;53(5):1341-1349.e3. doi: 10.1016/j.jvs.2010.11.113. Epub 2011 Feb 18.
5
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7
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8
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Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1687-94. doi: 10.1161/ATVBAHA.110.204529. Epub 2010 May 27.
9
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Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1118-26. doi: 10.1161/ATVBAHA.109.200873. Epub 2010 Apr 8.
10
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