Departments of Vascular Diseases and Clinical Chemistry, University Hospital MAS, Malmö, Sweden.
Angiology. 2010 Feb-Mar;61(1):113-8. doi: 10.1177/0003319709335906. Epub 2009 Jul 21.
Does thrombin activation seen in patients with abdominal aortic aneurysms (AAA) relate to the thrombus surface area or volume within the aneurysm?
A total of 130 patients with AAA were analyzed regarding levels of the complex between activated protein C-protein C inhibitor (APC-PCI) and AAA morphology. Analysis of APC-PCI complex was made using a sandwich immunofluorometric method.
Increased APC-PCI concentrations were seen in patients with AAA (0.44 microg/L; P < .001 compared with controls). The correlations of APC-PCI values were r = .13, P = .13 for aneurysm size, r = .08, P = .35 for thrombus surface area, and r = .13, P = .14 for thrombus volume. APC-PCI values elevated to 0.45 microg/L in 10 patients with AAA having no or very little thrombus mass.
Disappointingly, no correlation was found between thrombus surface area or volume and levels of the APC-PCI complex. Mechanisms other than the AAA-sac thrombus must be evaluated as cause of thrombin activation in patients with AAA.
腹主动脉瘤（AAA）患者中所见的凝血酶激活与瘤内血栓的表面积或体积有关吗？
分析了 130 例 AAA 患者的 APC-PCI 复合物水平与 AAA 形态之间的关系。使用夹心免疫荧光测定法进行 APC-PCI 复合物分析。
AAA 患者的 APC-PCI 浓度升高（0.44μg/L；与对照组相比，P<.001）。APC-PCI 值的相关性为 r =.13，P =.13（与瘤体大小相关），r =.08，P =.35（与血栓表面积相关），r =.13，P =.14（与血栓体积相关）。在 10 例 AAA 患者中，APC-PCI 值升高至 0.45μg/L，这些患者的血栓质量很少或没有。
令人失望的是，血栓表面积或体积与 APC-PCI 复合物水平之间没有相关性。除 AAA 囊内血栓外，还必须评估其他机制作为 AAA 患者凝血酶激活的原因。
