Roldán-Pallarés Manuela, Musa Abdalla-Sadiq, Hernandez-Montero Julian, Rollin Raquel, Bravo-Llatas Carmen, Fernández-Durango Raquel
Department of Ophthalmology, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain.
Retina. 2008 Jan;28(1):111-24. doi: 10.1097/IAE.0b013e31809ffad0.
To analyze if endothelin-1 (ET-1) may have an effect on ophthalmic artery (OA) blood flow velocities and intraocular pressure (IOP) in retinal detachment (RD).
Using radioimmunoassay, immunoreactive (IR) ET-1 levels were tested in both plasma and subretinal fluid (SRF) specimens from patients with RD, while only plasma specimens from normal (healthy) subjects were tested. OA Doppler sonography parameters and IOP were measured in eyes with RD, with and without proliferative vitreoretinopathy (PVR), their respective healthy fellow eyes, and normal eyes.
RD eyes had lower OA peak systolic velocity (PSV) and end diastolic velocity (EDV), higher resistivity index (RI), lower IOP, and higher plasma IR ET-1 levels than normal eyes (P < 0.0001). Eyes with PVR had lower OA PSV and EDV, higher RI, lower IOP, higher plasma IR ET-1 levels, and higher SRF IR ET-1 than eyes without PVR (P < 0.0001). A statistically significant linear correlation was found among OA parameters, IOP, and SRF IR ET-1 measurements.
Decreased OA blood flow velocities may explain lower IOP found in RD patients, and ET-1 levels may be responsible for both measurements.
分析内皮素-1（ET-1）是否可能对视网膜脱离（RD）患者的眼动脉（OA）血流速度和眼压（IOP）产生影响。
采用放射免疫分析法，检测RD患者血浆和视网膜下液（SRF）标本中的免疫反应性（IR）ET-1水平，而仅检测正常（健康）受试者的血浆标本。对患有RD且伴有或不伴有增殖性玻璃体视网膜病变（PVR）的患眼、其各自的健侧眼以及正常眼测量OA多普勒超声参数和IOP。
与正常眼相比，RD患眼的OA收缩期峰值速度（PSV）和舒张末期速度（EDV）较低，阻力指数（RI）较高，IOP较低，血浆IR ET-1水平较高（P < 0.0001）。与无PVR的患眼相比，伴有PVR的患眼的OA PSV和EDV较低，RI较高，IOP较低，血浆IR ET-1水平较高，SRF IR ET-1较高（P < 0.0001）。在OA参数、IOP和SRF IR ET-1测量值之间发现了具有统计学意义的线性相关性。
OA血流速度降低可能解释了RD患者眼压较低的原因，而ET-1水平可能与这两项测量结果均有关。
