Li Lin-feng, Liu Guangren, Wang Jing
Department of Dermatology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100083, China.
Contact Dermatitis. 2008 Feb;58(2):88-92. doi: 10.1111/j.1600-0536.2007.01260.x.
Prognosis of hand eczema (HE) has not been reported in China.
To investigate the etiology and outcome of HE in 655 consecutive patients patch tested with European standard series in Peking University Hospital in a 2-year period.
All patients were re-examined at 1 year after patch testing, and prognosis of dermatitis was evaluated by the rate of clearance of skin symptoms for at least 3 months without relapse before the evaluation.
Of 599 patients examined, 82 (13.7%) were HE. Allergic, irritant, and unclassified HE accounted for 23.2%, 17.1%, and 51.3% of HE, respectively. The overall clearance rate of HE was much lower than that of eczema elsewhere (18.3% versus 29.6%, P < 0.05, chi-squared test). 35.7% of patients with allergic HE and 26.3% with irritant HE cleared their lesions, of those with unclassified HE only 11.9% (P < 0.05, chi-squared test). The lowest healing rate (5.7%) was found in unclassified HE patients with disease duration over 6 months.
The outcome of HE was worse than eczema elsewhere. Allergic HE had a better prognosis than unclassified HE. Longer disease duration was the main risk factor for poor prognosis of unclassified HE.
中国尚未有关于手部湿疹（HE）预后的报道。
调查北京大学医院连续655例接受欧洲标准系列斑贴试验的患者在2年期间手部湿疹的病因及转归情况。
所有患者在斑贴试验后1年进行复查，通过评估皮肤症状在评估前至少3个月无复发的清除率来评价皮炎的预后。
在接受检查的599例患者中，82例（13.7%）为手部湿疹。变应性、刺激性和未分类的手部湿疹分别占手部湿疹的23.2%、17.1%和51.3%。手部湿疹的总体清除率远低于其他部位湿疹（18.3%对29.6%，P<0.05，卡方检验）。变应性手部湿疹患者中有35.7%、刺激性手部湿疹患者中有26.3%皮疹消退，而未分类手部湿疹患者中只有11.9%皮疹消退（P<0.05，卡方检验）。疾病持续时间超过6个月的未分类手部湿疹患者愈合率最低（5.7%）。
手部湿疹的转归比其他部位湿疹更差。变应性手部湿疹的预后优于未分类手部湿疹。疾病持续时间长是未分类手部湿疹预后不良的主要危险因素。
