Shah Neeral L, Zacharias Isabel, Khettry Urmila, Afdhal Nezam, Gordon Fredric D
Department of Gastroenterology, Lahey Clinic Medical Center, Burlington, Massachusetts 01805, USA.
Clin Gastroenterol Hepatol. 2008 Feb;6(2):255-8. doi: 10.1016/j.cgh.2007.11.010. Epub 2008 Jan 9.
BACKGROUND & AIMS: Methasteron is a nutritional supplement used to increase weight or accelerate the build-up of muscle mass. The aim of this study was to describe 5 cases of hepatotoxicity in patients using methasteron seen at tertiary-care medical centers.
A case report design was used.
Five previously healthy patients who used methasteron developed jaundice 2 weeks after discontinuation; they presented to a tertiary-care medical center 2 weeks later. Within another 2 to 3 weeks, bilirubin levels peaked. About 12 weeks after initial presentation, all cases resolved with no identifiable residual hepatic dysfunction.
Methasteron use can result in severe hepatotoxicity. Liver failure can worsen after initial presentation, especially within 2 weeks. With close observation and supportive care, acute hepatic injury should resolve.
美睾酮是一种营养补充剂，用于增加体重或加速肌肉量的积累。本研究的目的是描述在三级医疗中心就诊的5例使用美睾酮的患者发生肝毒性的情况。
采用病例报告设计。
5例此前健康的使用美睾酮的患者在停药2周后出现黄疸；2周后他们前往一家三级医疗中心就诊。在接下来的2至3周内，胆红素水平达到峰值。在初次就诊后约12周，所有病例均痊愈，未发现残留肝功能障碍。
使用美睾酮可导致严重肝毒性。初次就诊后肝功能衰竭可能会恶化，尤其是在2周内。通过密切观察和支持性治疗，急性肝损伤应可痊愈。
