García-Cortés Miren, Robles-Díaz Mercedes, Ortega-Alonso Aida, Medina-Caliz Inmaculada, Andrade Raul J
Servicio de Farmacología Clíınica and Unidad de Gestión Clínica (UGC) de Gastroenterología y Hepatología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), 29010 Málaga, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 Madrid, Spain.
Int J Mol Sci. 2016 Apr 9;17(4):537. doi: 10.3390/ijms17040537.
Dietary supplements (DS) are extensively consumed worldwide despite unproven efficacy. The true incidence of DS-induced liver injury (DSILI) is unknown but is probably under-diagnosed due to the general belief of safety of these products. Reported cases of herbals and DS-induced liver injury are increasing worldwide. The aim of this manuscript is to report a tabular listing with a description of DS associated with hepatotoxicity as well as review the phenotype and severity of DSILI. Natural remedies related to hepatotoxicity can be divided into herbal product-induced liver injury and DS-induced liver injury. In this article, we describe different DS associated with liver injury, some of them manufactured DS containing several ingredients (Herbalife™ products, Hydroxycut™, LipoKinetix™, UCP-1 and OxyELITE™) while others have a single ingredient (green tea extract, linoleic acid, usnic acid, 1,3-Dimethylamylamine, vitamin A, Garcinia cambogia and ma huang). Additional DS containing some of the aforementioned ingredients implicated in liver injury are also covered. We have also included illicit androgenic anabolic steroids for bodybuilding in this work, as they are frequently sold under the denomination of DS despite being conventional drugs.
尽管膳食补充剂（DS）的功效未经证实，但在全球范围内仍被广泛食用。DS诱导的肝损伤（DSILI）的真实发病率尚不清楚，但由于人们普遍认为这些产品安全，可能存在诊断不足的情况。在全球范围内，草药和DS诱导的肝损伤的报告病例正在增加。本手稿的目的是报告一份表格清单，描述与肝毒性相关的DS，并回顾DSILI的表型和严重程度。与肝毒性相关的天然药物可分为草药产品诱导的肝损伤和DS诱导的肝损伤。在本文中，我们描述了与肝损伤相关的不同DS，其中一些是含有多种成分的制成品DS（康宝莱™产品、Hydroxycut™、LipoKinetix™、UCP-1和OxyELITE™），而其他则含有单一成分（绿茶提取物、亚油酸、松萝酸、1,3-二甲基戊胺、维生素A、藤黄果和麻黄）。还涵盖了含有一些上述与肝损伤有关成分的其他DS。在这项工作中，我们还纳入了用于健身的非法雄激素合成代谢类固醇，因为尽管它们是传统药物，但经常以DS的名义出售。
