Das Siddartha, Brudvig Gary W, Crabtree Robert H
Yale Chemistry, New Haven, CT 06520, USA.
Chem Commun (Camb). 2008 Jan 28(4):413-24. doi: 10.1039/b710355g. Epub 2007 Sep 14.
Traditional methods for selectivity control in homogeneous transition metal catalysis either employ steric effects in a binding pocket or chelate control. In a supramolecular strategy, encapsulation of the substrate can provide useful shape and size selectivity. A fully developed molecular recognition strategy involving hydrogen bonding or solvophobic forces has given almost completely regioselective functionalization of remote, unactivated C-H bonds.
均相过渡金属催化中用于选择性控制的传统方法要么利用结合口袋中的空间效应，要么采用螯合控制。在超分子策略中，底物的封装可以提供有用的形状和尺寸选择性。一种涉及氢键或疏溶剂力的成熟分子识别策略几乎实现了对远程未活化C-H键的完全区域选择性官能化。
