Kademian Monique, Bechtel Mark, Zirwas Matt
Division of Dermatology, Ohio State University, Columbus, USA.
J Drugs Dermatol. 2007 Dec;6(12):1220-1.
Nicotinamide is the amide form of niacin and has anti-inflammatory properties that have led to its use in the treatment of several inflammatory dermatologic conditions, such as rosacea. Niacin has established its role in the prevention of coronary artery disease. Cutaneous flushing is a well-known and often dose-limiting side effect of niacin therapy, which does not occur with nicotinamide. We report a patient with rosacea who developed new onset flushing due to unauthorized substitution of niacin for nicotinamide. The anti-inflammatory mechanisms of nicotinamide and flushing mechanisms of niacin are discussed.
烟酰胺是烟酸的酰胺形式，具有抗炎特性，已被用于治疗多种炎症性皮肤病，如酒渣鼻。烟酸在预防冠状动脉疾病方面已确立了其作用。皮肤潮红是烟酸治疗中一种众所周知且常限制剂量的副作用，而烟酰胺治疗不会出现这种情况。我们报告了一名酒渣鼻患者，因未经授权将烟酸替代烟酰胺而出现新发潮红。本文讨论了烟酰胺的抗炎机制和烟酸的潮红机制。
