量子点：在泌尿肿瘤学中的新兴应用

Quantum dots: emerging applications in urologic oncology.

作者信息

Shi Chunmeng, Zhu Ying, Cerwinka Wolfgang H, Zhau Haiyen E, Marshall Fray F, Simons Jonathan W, Nie Shuming, Chung Leland W K

机构信息

Molecular Urology and Therapeutics Program, Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA.

出版信息

Urol Oncol. 2008 Jan-Feb;26(1):86-92. doi: 10.1016/j.urolonc.2007.03.018.

DOI:10.1016/j.urolonc.2007.03.018

PMID:18190836

Abstract

Quantum dots (QDs), nanometer-sized fluorescent probes with unique optical and electronic properties, offer a promising and powerful tool for cancer imaging and diagnostics. For the past few years, QDs were actively developed for biomolecular profiling of cancer biomarkers, in vivo tumor imaging, and even targeted drug delivery. These emerging applications are currently being improved and integrated into clinical practice. In this article, we describe the development of multifunctional QDs and their potential applications in oncology, with a particular emphasis on the diagnosis, prognosis, and treatment of urologic cancers.

摘要

量子点（QDs）是具有独特光学和电子特性的纳米级荧光探针，为癌症成像和诊断提供了一种有前景且强大的工具。在过去几年中，量子点被积极开发用于癌症生物标志物的生物分子分析、体内肿瘤成像，甚至靶向药物递送。这些新兴应用目前正在不断改进并融入临床实践。在本文中，我们描述了多功能量子点的发展及其在肿瘤学中的潜在应用，特别强调了泌尿系统癌症的诊断、预后和治疗。