Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
Adv Drug Deliv Rev. 2015 Dec 1;95:2-14. doi: 10.1016/j.addr.2015.08.004. Epub 2015 Sep 4.
A field of recent diagnostics and therapeutics has been advanced with quantum dots (QDs). QDs have developed into new formats of biomolecular sensing to push the limits of detection in biology and medicine. QDs can be also utilized as bio-probes or labels for biological imaging of living cells and tissues. More recently, QDs has been demonstrated to construct a multifunctional nanoplatform, where the QDs serve not only as an imaging agent, but also a nanoscaffold for diagnostic and therapeutic modalities. This review highlights the promising applications of multi-functionalized QDs as advanced nanosensors for diagnosing cancer and as innovative fluorescence probes for in vitro or in vivo stem cell imaging in regenerative medicine.
近年来，量子点（QD）在诊断和治疗领域取得了进展。QD 已经发展成为生物分子传感的新形式，以推动生物学和医学检测的极限。QD 也可用作生物探针或标签，用于活细胞和组织的生物成像。最近，QD 已被证明可构建多功能纳米平台，其中 QD 不仅可用作成像剂，而且可用作诊断和治疗模式的纳米支架。本文综述了多功能化 QD 作为先进的纳米传感器在癌症诊断中的应用以及作为创新的荧光探针在再生医学中用于体外或体内干细胞成像的有希望的应用。
