Yang Yao-Hsu, Chuang Ya-Hui, Wang Li-Chieh, Huang Hsin-Yi, Gershwin M Eric, Chiang Bor-Luen
Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
Autoimmun Rev. 2008 Jan;7(3):179-84. doi: 10.1016/j.autrev.2007.11.012. Epub 2007 Dec 3.
Henoch-Schönlein purpura (HSP) is a common but enigmatic systemic small vessel vasculitis that primarily affects children. Although the etiology of this disease is unknown, there are tantalizing clues on the natural history and immunopathogenesis. This article reviews these clues including aspects of disease-associated pathogens, immune regulation, with a focus on IgA, and finally the immunogenetic background of host. We also present a hypothetical model for the development of HSP and submit that this paradigm will be a generic one for similar vasculopathies.
过敏性紫癜（HSP）是一种常见但神秘的系统性小血管炎，主要影响儿童。尽管这种疾病的病因尚不清楚，但在其自然史和免疫发病机制方面有一些诱人的线索。本文回顾了这些线索，包括与疾病相关的病原体、免疫调节方面，重点是免疫球蛋白A（IgA），最后是宿主的免疫遗传背景。我们还提出了一个过敏性紫癜发展的假说模型，并认为这个范式将是类似血管病变的通用模型。
