Lim Danforn C E, Cheng Lisa N C, Wong Felix W S
Integrative Medicine Research, School of Medicine, Sydney, University of Notre Dame Australia.
Aust Fam Physician. 2009 May;38(5):321-4.
Henoch-Schönlein purpura is the most common form of systemic vasculitis in the paediatric setting with 90% of cases occuring in childhood. Although diagnosis in the primary care setting may be difficult, it is vital in order to avoid significant complications.
This article outlines the pathogenesis, clinical manifestations and classification of Henoch-Schönlein purpura and details evidence based investigations and management.
Henoch-Schönlein purpura is a self limiting disease characterised by a tetrad of clinical manifestations that vary in occurrence and order of presentation. There is no single diagnostic test to confirm Henoch- Schönlein purpura; diagnosis depends on recognition of clinical manifestations. Management usually occurs in the ambulatory setting and is mainly supportive. Priorities include symptom relief and preventive therapy to reduce the risk of complications. Further trials to clarify the role of glucocorticosteroids are needed before a definitive role for steroids in the management of Henoch-Schönlein purpura can be established.
过敏性紫癜是儿科最常见的系统性血管炎形式，90%的病例发生在儿童期。虽然在初级保健环境中诊断可能困难，但为避免严重并发症，诊断至关重要。
本文概述过敏性紫癜的发病机制、临床表现和分类，并详细介绍基于证据的检查和管理。
过敏性紫癜是一种自限性疾病，其特征为一系列临床表现，这些表现的出现频率和顺序各不相同。没有单一的诊断测试可确诊过敏性紫癜；诊断依赖于对临床表现的识别。管理通常在门诊进行，主要是支持性的。重点包括缓解症状和预防性治疗以降低并发症风险。在确定糖皮质激素在过敏性紫癜管理中的明确作用之前，需要进一步试验以阐明其作用。
