Baldini Chiara, Giusti Laura, Bazzichi Laura, Lucacchini Antonio, Bombardieri Stefano
Department of Internal Medicine, Rheumatology Unit, University of Pisa, Via Roma 67, 56126 Pisa, Italy.
Autoimmun Rev. 2008 Jan;7(3):185-91. doi: 10.1016/j.autrev.2007.11.002. Epub 2007 Nov 29.
The clinical entity of secondary Sjögren's syndrome (SS) is controversial and the relationship with primary SS and other systemic autoimmune diseases is still far from being completely understood. In the last few years, proteomic approaches have been applied with a growing interest in the search for diagnostic biomarkers for many rheumatic diseases and it is possible that, in the near future, proteomic analysis of human saliva could help in distinguishing also primary from secondary SS. This review summarizes the state of the art of proteomic analysis of human saliva in the diagnosis of connective diseases focusing its advantages, limits and future perspectives.
继发性干燥综合征（SS）的临床实体存在争议，其与原发性SS及其他系统性自身免疫性疾病的关系仍远未完全明晰。在过去几年中，蛋白质组学方法已被应用于寻找多种风湿性疾病的诊断生物标志物，且兴趣日益浓厚，在不久的将来，对人类唾液进行蛋白质组学分析也有可能有助于区分原发性和继发性SS。本综述总结了人类唾液蛋白质组学分析在结缔组织疾病诊断中的现状，重点阐述了其优势、局限性及未来前景。
