Hunt Patricia A, Hassold Terry J
School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164-4660, USA.
Trends Genet. 2008 Feb;24(2):86-93. doi: 10.1016/j.tig.2007.11.010. Epub 2008 Jan 14.
Critical events of oogenesis occur during three distinct developmental stages: meiotic initiation in the fetal ovary, follicle formation in the perinatal period, and oocyte growth and maturation in the adult. Evidence from studies in humans and mice suggests that the genetic quality of the egg may be influenced by events at each of these stages. Recent experimental studies add additional complexity, suggesting that environmental influences might adversely affect all three stages. Thus, understanding the molecular control of oogenesis during these critical developmental windows will not only contribute to an understanding of human aneuploidy, but also provide a means of assessing potential effects of environmental exposures on human reproductive health.
胎儿卵巢中的减数分裂起始、围产期的卵泡形成以及成年期的卵母细胞生长和成熟。来自人类和小鼠研究的证据表明，卵子的遗传质量可能受到这些阶段中每个阶段事件的影响。最近的实验研究增加了额外的复杂性，表明环境影响可能对所有三个阶段产生不利影响。因此，了解这些关键发育窗口期间卵子发生的分子控制不仅有助于理解人类非整倍体，还提供了一种评估环境暴露对人类生殖健康潜在影响的方法。
