细胞凋亡紊乱：原发性免疫缺陷病中自身免疫的机制
Disorders of apoptosis: mechanisms for autoimmunity in primary immunodeficiency diseases.
作者信息
Oliveira João Bosco, Gupta Sudhir
机构信息
Molecular Immunology and Genetics Section, Universidade de São Paulo, São Paulo, Brazil.
出版信息
J Clin Immunol. 2008 May;28 Suppl 1:S20-8. doi: 10.1007/s10875-007-9161-4. Epub 2008 Jan 12.
PMID:18193340
Abstract
A number of primary immunodeficiency diseases represent a paradox of immunodeficiency and autoimmunity. In this minireview, we present basic concepts of apoptosis and disorder of apoptosis as one of the mechanisms to explain such a paradox between immunodeficiency and autoimmunity, which is exemplified by autoimmune lymphoproliferative syndrome (ALPS).
摘要
许多原发性免疫缺陷病表现出免疫缺陷与自身免疫的矛盾现象。在这篇迷你综述中，我们阐述细胞凋亡的基本概念以及细胞凋亡紊乱，将其作为解释免疫缺陷与自身免疫之间这种矛盾现象的机制之一，自身免疫性淋巴细胞增生综合征（ALPS）就是一个例证。
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