Maleville J, Larregue M, Ball M, Geniaux M
Hôpital des Enfants, Bordeaux, France.
Bull Soc Pathol Exot. 1991;84(5 Pt 5):609-13.
Together with the new rise of recent syphilis in the adult woman, congenital syphilis reappears sporadically in our countries, where prophylactic measures (prenatal serology) are sometimes defeated. It remains much more frequent in developing countries. One should know how to interpret a positive serology in a newborn, as it may only reflect passive transplacental transfer of maternal antibodies. One should on the other hand think of syphilis again when the clinical signs are more or less suggestive, the typical picture not being, by far, the most frequent. In spite of the efficacy of Penicillin G: 50,000 U/kg/day during 10 days, neonatal death rate for congenital syphilis is in the neighbourhood of 10%. Our major effort should therefore be aimed at prevention.
随着成年女性近期梅毒新发病例的增加,先天性梅毒在我们国家也偶尔出现,在这些国家,预防措施(产前血清学检查)有时会失效。在发展中国家,先天性梅毒仍然更为常见。人们应该知道如何解读新生儿血清学检查呈阳性的结果,因为这可能仅反映母体抗体经胎盘的被动转移。另一方面,当临床症状或多或少提示有梅毒时,就应该再次考虑梅毒的可能,典型症状远非最常见的表现。尽管青霉素G有疗效(10天内每日50,000 U/kg),但先天性梅毒的新生儿死亡率仍在10%左右。因此,我们的主要努力应该放在预防上。