从老鹳草属植物丝石竹根中分离得到具有强α-葡萄糖苷酶抑制活性的新型三萜皂苷。

New triterpenoid saponins with strong alpha-glucosidase inhibitory activity from the roots of Gypsophila oldhamiana.

作者信息

Luo Jian-Guang, Ma Li, Kong Ling-Yi

机构信息

Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.

出版信息

Bioorg Med Chem. 2008 Mar 15;16(6):2912-20. doi: 10.1016/j.bmc.2007.12.053. Epub 2008 Jan 1.

DOI:10.1016/j.bmc.2007.12.053

PMID:18194870

Abstract

Seven new triterpenoid saponins (1-7), have been isolated and elucidated from the roots of Gypsophila oldhamiana together with five known triterpenoid saponins (8-12). These saponins which could be classified into three series: 3-O-monoglucosides (1, 8, 9), 28-O-monoglucosides (2-4, 12) and 3, 28-O-bidesmosides (5-7, 10, 11), have been evaluated for their alpha-glucosidase inhibition activity. As a result, the preliminary structure-activity relationships were discussed based on the position of sugar linkage attached to the aglycone, and 28-O-monoglucosides 2-4 and 12 showed significant inhibitory activities on alpha-glucosidase.

摘要

从老鹤草的根部分离并鉴定出七种新的三萜皂苷（1-7）以及五种已知的三萜皂苷（8-12）。这些皂苷可分为三个系列：3-O-单葡萄糖苷（1、8、9）、28-O-单葡萄糖苷（2-4、12）和3,28-O-双糖链苷（5-7、10、11），并对它们的α-葡萄糖苷酶抑制活性进行了评估。结果，基于糖苷配基上连接糖的位置讨论了初步的构效关系，并且28-O-单葡萄糖苷2-4和12对α-葡萄糖苷酶显示出显著的抑制活性。