椭圆悬钩子变种倒心形叶悬钩子中的三萜皂苷
Triterpenoid saponins from Rubus ellipticus var. obcordatus.
作者信息
Li Wei, Fu Hongwei, Bai Hong, Sasaki Tatsunori, Kato Hiroyoshi, Koike Kazuo
机构信息
Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
出版信息
J Nat Prod. 2009 Oct;72(10):1755-60. doi: 10.1021/np900237a.
Ten new triterpenoid saponins (1-10), named rubusides A-J, and 21 known saponins (11-31) were isolated from the roots of Rubus ellipticus var. obcordatus. The structures of 1-10 were established on the basis of spectroscopic analyses, mainly NMR and MS, and chemical degradations. The compounds demonstrated inhibitory activities against alpha-glucosidase with IC50 values in the range 0.65-3.09 mM.
从椭圆悬钩子倒心形变种的根中分离出10种新的三萜皂苷（1-10），命名为悬钩子苷A-J，以及21种已知皂苷（11-31）。通过光谱分析（主要是核磁共振和质谱）以及化学降解确定了1-10的结构。这些化合物对α-葡萄糖苷酶具有抑制活性，IC50值在0.65-3.09 mM范围内。
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