Tong Dan, Heinze Georg, Schremmer Michael, Schuster Eva, Czerwenka Klaus, Leodolter Sepp, Zeillinger Robert
Division of Gynaecology, Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria.
Oncol Res. 2007;16(10):465-70. doi: 10.3727/096504007783338322.
MTA1 was reported as a metastasis-associated gene. Tumors with higher MTA1 mRNA level were shown to have higher rates of invasion and lymph node metastasis and tended to have higher rates of vascular involvement. The majority of invasive breast carcinomas were demonstrated to overexpress MTA1 compared to surrounding normal tissues. MTA1 was also found to be more expressed in metastatic breast cancer cell lines than in nonmetastatic ones. Originally we were interested in analyzing factors differently expressed in invasive and noninvasive breast cancer cell lines. Therefore we analyzed expression of MTA1 together with several other genes in correlation with cell invasiveness in 25 breast epithelial cell lines. Furthermore, we analyzed it in 90 primary breast tumor tissues and examined its correlation with expression of estrogen receptor, progesterone receptor, plasminogen activator inhibitor-1, E-cadherin, histopathological data, disease-free survival, and overall survival. Our results demonstrated that MTA1 expression was significantly higher in noninvasive cell lines than in invasive ones. It also correlated positively with expression of noninvasive factors and reverse correlated with invasive factors in both cell lines and tumor tissues.
MTA1被报道为一种与转移相关的基因。研究表明，MTA1 mRNA水平较高的肿瘤具有更高的侵袭率和淋巴结转移率，并且往往有更高的血管受累率。与周围正常组织相比，大多数浸润性乳腺癌被证明过度表达MTA1。还发现MTA1在转移性乳腺癌细胞系中的表达高于非转移性细胞系。最初我们感兴趣的是分析浸润性和非浸润性乳腺癌细胞系中差异表达的因素。因此，我们在25个乳腺上皮细胞系中分析了MTA1以及其他几个基因的表达与细胞侵袭性的相关性。此外，我们在90个原发性乳腺肿瘤组织中进行了分析，并检测了其与雌激素受体、孕激素受体、纤溶酶原激活物抑制剂-1、E-钙黏蛋白的表达、组织病理学数据、无病生存期和总生存期的相关性。我们的结果表明，MTA1在非浸润性细胞系中的表达明显高于浸润性细胞系。在细胞系和肿瘤组织中，它还与非浸润性因子的表达呈正相关，与浸润性因子呈负相关。
