Purser Sophie, Moore Peter R, Swallow Steve, Gouverneur Véronique
The Chemistry Research Laboratory, 12 Mansfield Road, Oxford, UK OX1 3TA.
Chem Soc Rev. 2008 Feb;37(2):320-30. doi: 10.1039/b610213c. Epub 2007 Dec 13.
It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
显而易见，含氟化合物在药物化学领域成绩斐然，并将在为治疗应用提供先导化合物方面持续发挥作用。本专题综述列举了一些著名的含氟药物及其作用方式，并展开讨论以阐明氟取代对药物效力的作用和影响。
