在自身免疫性肝炎活动期，抗α-辅肌动蛋白抗体与抗单链DNA抗体发生交叉反应。
Anti-alpha-actinin antibodies cross-react with anti-ssDNA antibodies in active autoimmune hepatitis.
作者信息
Renaudineau Yves, Dalekos Geogios N, Guéguen Paul, Zachou Kalliopi, Youinou Pierre
机构信息
Brest University Medical School Hospital, Brest Cedex, France.
出版信息
Clin Rev Allergy Immunol. 2008 Jun;34(3):321-5. doi: 10.1007/s12016-007-8050-1.
Recently, we have observed that the association of anti-F-actin autoantibodies (Abs) with anti-alpha-actinin Abs (double reactivity) was correlated with liver disease activity in autoimmune hepatitis type 1 (AIH-1; Guéguen et al., J Clin Immunol 26:495-505, 2006). As anti-alpha-actinin Abs are also associated with anti-single-stranded (ss) DNA in 16 of 50 (32%) AIH-1 patients, compared with 16 of 401 (4.0%) liver disease control patients, we sought to characterize these Abs in AIH-1. When associated, anti-ssDNA Abs cross-react with anti-alpha-actinin Abs, but neither with anti-double-stranded DNA Abs nor with anti-F-actin Abs. Furthermore, anti-alpha-actinin Abs are associated with high-avidity anti-ssDNA Abs in AIH-1. In addition, double reactivity against alpha-actinin and ssDNA was correlated with clinical and histological activity of the disease and untreated AIH-1 patients.
最近，我们观察到抗F-肌动蛋白自身抗体（Abs）与抗α-辅肌动蛋白抗体（双重反应性）的关联与1型自身免疫性肝炎（AIH-1）的肝脏疾病活动相关（Guéguen等人，《临床免疫学杂志》26:495-505，2006年）。由于在50例AIH-1患者中有16例（32%）抗α-辅肌动蛋白抗体也与抗单链（ss）DNA相关，而在401例肝病对照患者中只有16例（4.0%）如此，我们试图对AIH-1中的这些抗体进行特征描述。当相关时，抗ssDNA抗体与抗α-辅肌动蛋白抗体发生交叉反应，但与抗双链DNA抗体和抗F-肌动蛋白抗体均无交叉反应。此外，在AIH-1中抗α-辅肌动蛋白抗体与高亲和力抗ssDNA抗体相关。另外，针对α-辅肌动蛋白和ssDNA的双重反应性与疾病的临床和组织学活动以及未经治疗的AIH-1患者相关。
Zotero 插件