Vecchiarelli Anna
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy.
Crit Rev Immunol. 2007;27(6):547-57. doi: 10.1615/critrevimmunol.v27.i6.50.
Many capsular polysaccharide antigens are generally considered to be classic T-cell independent antigens that stimulate humoral response. This response is poor and short lived due to the absence of T-cell involvement. Recent emerging evidence suggests that fungal capsular polysaccharides may negatively affect T-cell response. This effect is indirectly mediated by antigen-presenting cells that sense microbial polysaccharides and manage T-cell response. This review will revisit the role of the cryptococcal capsular polysaccharide as a nonconventional regulator of natural and adaptive immune response, revealing the hidden nature of its poor immunogenicity and novel opportunities for the biomedical exploitation of this nontoxic compound.
许多荚膜多糖抗原通常被认为是刺激体液反应的经典非T细胞依赖性抗原。由于缺乏T细胞参与，这种反应较弱且持续时间短。最近新出现的证据表明，真菌荚膜多糖可能对T细胞反应产生负面影响。这种效应是由感知微生物多糖并调控T细胞反应的抗原呈递细胞间接介导的。本综述将重新审视新型隐球菌荚膜多糖作为天然和适应性免疫反应的非常规调节因子的作用，揭示其免疫原性差的隐藏本质以及对这种无毒化合物进行生物医学开发的新机会。
