Cryer Philip E
Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, 660 South Euclid Ave, MO 63110, USA.
Clin Sci (Lond). 2008 May;114(9):589-90. doi: 10.1042/CS20070434.
Glucagon, in the setting of absolute or relative insulin deficiency, is thought to contribute to the pathogenesis of hyperglycaemia in diabetes, but much of the evidence is extrapolated from short-term studies to the long-term condition. In the present issue of Clinical Science, Li and co-workers report that infusion of glucagon raised fasting plasma glucose concentrations and impaired glucose tolerance over 4 weeks in mice, thus demonstrating a sustained glycaemic effect of hyperglucagonaemia. Nonetheless, compelling evidence that glucagon contributes to the pathogenesis of hyperglycaemia in diabetes awaits long-term selective reduction of glucagon secretion or action in humans.
在绝对或相对胰岛素缺乏的情况下，胰高血糖素被认为与糖尿病高血糖的发病机制有关，但许多证据是从短期研究推断至长期情况的。在本期《临床科学》中，李及其同事报告称，在小鼠中输注胰高血糖素4周后会提高空腹血糖浓度并损害糖耐量，从而证明高胰高血糖素血症具有持续的血糖效应。尽管如此，关于胰高血糖素导致糖尿病高血糖发病机制的确凿证据仍有待于在人体中对胰高血糖素分泌或作用进行长期选择性降低的研究。
