Osmani Naël, Etienne-Manneville Sandrine
Groupe Polarité et Migration Cellulaires, Institut Pasteur, 25 rue du Docteur Roux, Paris Cedex 15, France.
Med Sci (Paris). 2008 Jan;24(1):61-4. doi: 10.1051/medsci/200824161.
Polarity is a fundamental feature of all organisms both during development and in the adult. This reflects the key role of cell polarity during basic fundamental processes such as cell division, cell differentiation and cell migration. The control of cell polarity relies on functionally conserved proteins. Among these, Scribble, initially identified as a tumor suppressor gene in Drosophila, has been first involved in epithelial polarity. More recently Scribble function has been implicated in neuronal polarity and polarized cell migration. Scribble joins the growing family of tumor suppressors that play a key and conserved function in cell polarity. Scribble illustrates the more and more obvious link between regulation of cell polarity, cell transformation and tumor formation.
极性是所有生物体在发育过程中和成年期的一个基本特征。这反映了细胞极性在细胞分裂、细胞分化和细胞迁移等基本过程中的关键作用。细胞极性的控制依赖于功能保守的蛋白质。其中，最初在果蝇中被鉴定为肿瘤抑制基因的Scribble首先参与上皮极性。最近，Scribble的功能与神经元极性和极化细胞迁移有关。Scribble加入了在细胞极性中发挥关键和保守功能的肿瘤抑制因子不断增加的家族。Scribble说明了细胞极性调节、细胞转化和肿瘤形成之间越来越明显的联系。
