Zlatohlávek L, Zídková K, Vrablík M, Haas T, Prusíková M, Svobodová H, Ceska R
Third Medical Department, First Faculty of Medicine and General Teaching Hospital, Charles University, Prague, Czech Republic.
Physiol Res. 2008;57(5):777-784. doi: 10.33549/physiolres.931133. Epub 2008 Jan 17.
Lipoprotein(a) [Lp(a)] comprises of an LDL particle and apolipoprotein(a) [apo(a)] and its elevated levels are considered a risk factor for atherosclerosis. The aim of our study was to find out whether elevated Lp(a) levels are associated with increased risk of atherosclerosis in patients with multiple other risk factors. We further tested the association of three polymorphisms of the apo(a) gene promoter with Lp(a) levels. No significant correlation was detected between Lp(a) levels and lipid and clinical parameters tested. The study demonstrated a significantly (p=0.0219) elevated Lp(a) level (mean 28+/-35 mg/dl, median 0.14) in patients with coronary heart disease (CHD). In a group with premature CHD the correlation was not significant anymore. There was a significant correlation between polymorphic loci of the promoter region of apo(a) gene and Lp(a) levels (+93C T, p=0.0166, STR, p<0.0001). Our study suggests that elevated Lp(a) level is an independent risk factor of CHD in carriers of other important CHD risk factors. Observed association of sequence variants of the promoter of apo(a) gene with Lp(a) levels is caused in part due to linkage to a restricted range of apo(a) gene length isoforms.
脂蛋白(a)[Lp(a)]由一个低密度脂蛋白颗粒和载脂蛋白(a)[apo(a)]组成，其水平升高被认为是动脉粥样硬化的一个危险因素。我们研究的目的是确定在具有多种其他危险因素的患者中，Lp(a)水平升高是否与动脉粥样硬化风险增加相关。我们进一步检测了apo(a)基因启动子的三种多态性与Lp(a)水平的关联。未检测到Lp(a)水平与所检测的血脂及临床参数之间存在显著相关性。该研究表明，冠心病(CHD)患者的Lp(a)水平显著升高(p = 0.0219)(平均28±35mg/dl，中位数0.14)。在早发性冠心病组中，这种相关性不再显著。apo(a)基因启动子区域的多态性位点与Lp(a)水平之间存在显著相关性(+93C>T，p = 0.0166，STR，p<0.0001)。我们的研究表明，在具有其他重要冠心病危险因素的携带者中，Lp(a)水平升高是冠心病的一个独立危险因素。观察到的apo(a)基因启动子序列变异与Lp(a)水平的关联部分是由于与apo(a)基因长度异构体的有限范围连锁所致。
