Glover E J, Leland M M, Dick E J, Hubbard G B
Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
J Med Primatol. 2008 Feb;37(1):18-25. doi: 10.1111/j.1600-0684.2007.00217.x.
Gastroesophageal reflux disease (GERD) is increasingly prevalent in the human population. Current animal models require surgical or other manipulation to produce symptoms. An animal model that exhibits spontaneous GERD would provide the opportunity for much-needed research examining the susceptibility, diagnosis, and treatment of GERD.
Eight baboons (Papio hamadryas sp.) were diagnosed with GERD histopathologically using biopsies or postmortem tissues.
The disease was characterized by a spectrum of symptoms comparable with that found in the human population. Some subjects had no gross signs of clinical disease, but were diagnosed by histopathological examination. Almost all subjects presented with at least one clinical sign of the disease. Regurgitation was the most common.
The baboon may be a superior animal model for GERD research because it is a naturally occurring model and is anatomically and physiologically similar to humans.
胃食管反流病（GERD）在人群中的发病率日益增加。目前的动物模型需要手术或其他操作来产生症状。一种表现出自发性GERD的动物模型将为开展急需的关于GERD易感性、诊断和治疗的研究提供机会。
使用活检或死后组织，通过组织病理学诊断了八只狒狒（阿拉伯狒狒）患有GERD。
该疾病的特征是一系列与人类相似的症状。一些受试者没有明显的临床疾病体征，但通过组织病理学检查被诊断出来。几乎所有受试者都至少出现了该疾病的一种临床体征。反流是最常见的。
狒狒可能是GERD研究的一种优越动物模型，因为它是一种自然发生的模型，在解剖学和生理学上与人类相似。
