化学物质的运输和转化在人类病理生理学的生物物理学中的作用。

Roles of chemical species transport and transformation in the biophysics of human pathophysiology.

作者信息

Olanrewaju Kazeem B, Ford Versypt Ashlee N

机构信息

Department of Chemical Engineering, Prairie View A&M University, Prairie View, TX USA.

Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY USA.

出版信息

NPJ Biol Phys Mech. 2025;2(1):20. doi: 10.1038/s44341-025-00025-3. Epub 2025 Aug 6.

DOI:10.1038/s44341-025-00025-3

PMID:40786563

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12328227/

Abstract

This review focuses on the roles of chemical species transport and biochemical and biophysical transformation within the gastrointestinal and immune systems and interactions with tissue structure and biomechanics in the mechanisms of pathophysiological conditions including gastrointestinal reflux disease and allergic responses. Combinations of biophysical and biochemical techniques are needed to unravel the complex interplay between transport and transformation to develop more effective interventions and ultimately improve patient outcomes.

摘要

本综述聚焦于化学物质在胃肠道和免疫系统中的运输、生化及生物物理转化作用，以及在包括胃食管反流病和过敏反应等病理生理状况机制中与组织结构和生物力学的相互作用。需要结合生物物理和生化技术来揭示运输与转化之间复杂的相互作用，以开发更有效的干预措施并最终改善患者预后。