Roles of chemical species transport and transformation in the biophysics of human pathophysiology.

This review focuses on the roles of chemical species transport and biochemical and biophysical transformation within the gastrointestinal and immune systems and interactions with tissue structure and biomechanics in the mechanisms of pathophysiological conditions including gastrointestinal reflux disease and allergic responses. Combinations of biophysical and biochemical techniques are needed to unravel the complex interplay between transport and transformation to develop more effective interventions and ultimately improve patient outcomes.