Danjo Akiko, Yamaguchi Kanako, Fujimoto Kazuma, Saitoh Toshihito, Inamori Masahiko, Ando Takashi, Shimatani Tomohiko, Adachi Kyoichi, Kinjo Fukunori, Kuribayashi Shiko, Mitsufuji Shoji, Fujiwara Yasuhiro, Koyama Shigeki, Akiyama Junichi, Takagi Atsushi, Manabe Noriaki, Miwa Hiroto, Shimoyama Yasuyuki, Kusano Motoyasu
Department of Internal Medicine, Saga Medical School, Saga 849-8501, Japan.
J Gastroenterol Hepatol. 2009 Apr;24(4):633-8. doi: 10.1111/j.1440-1746.2008.05747.x. Epub 2009 Jan 12.
We compared endoscopic findings of the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG), a written questionnaire developed in Japan, to that for the questionnaire for the diagnosis of reflux esophagitis (QUEST) for the diagnosis of reflux esophagitis.
We registered 475 patients with untreated symptoms of upper abdominal pain (male/female: 252/223, average age 52.4 +/- 17.8 years). Subjects were assessed first with the FSSG and QUEST questionnaires, then by endoscopy, before allocation to a gastric ulcer (GU), duodenal ulcer (DU), gastroesophageal reflux disease (GERD) or functional dyspepsia (FD) group.
On the basis of the endoscopic findings the diagnoses for the 475 subjects were as follows: FD 52.2%, DU 7.6%, GU 7.8%, and GERD 32.4% (Grade M 10.1%, Grade A + B 20.2%, Grade C + D 2.3%). There was no difference between the FSSG and QUEST in sensitivity, specificity or accuracy for any condition. The FSSG score rose with increasing endoscopic severity of GERD, but there was no correlation between the QUEST score and endoscopic severity. The FSSG total score was inferior to QUEST in terms of distinguishing GERD from other conditions, but when only the questions relating to reflux symptoms were used, the FSSG was able to distinguish GERD from other conditions as well as QUEST.
The FSSG score reflects the severity of the endoscopic findings of GERD.
我们比较了日本开发的用于诊断反流性食管炎的胃食管反流病症状频率量表（FSSG）与反流性食管炎诊断问卷（QUEST）的内镜检查结果。
我们登记了475例未经治疗的上腹部疼痛患者（男/女：252/223，平均年龄52.4±17.8岁）。在将受试者分配到胃溃疡（GU）、十二指肠溃疡（DU）、胃食管反流病（GERD）或功能性消化不良（FD）组之前，先用FSSG和QUEST问卷进行评估，然后进行内镜检查。
根据内镜检查结果，475例受试者的诊断如下：FD占52.2%，DU占7.6%，GU占7.8%，GERD占32.4%（M级占10.1%，A级+B级占20.2%，C级+D级占2.3%）。FSSG和QUEST在任何情况下的敏感性、特异性或准确性均无差异。FSSG评分随GERD内镜严重程度的增加而升高，但QUEST评分与内镜严重程度之间无相关性。在区分GERD与其他疾病方面，FSSG总分不如QUEST，但仅使用与反流症状相关的问题时，FSSG能够像QUEST一样区分GERD与其他疾病。
FSSG评分反映了GERD内镜检查结果的严重程度。
