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胃食管反流病、消化不良和肠易激综合征重叠的患病率及危险因素：一项基于人群的研究。

Prevalence and risk factors for overlaps between gastroesophageal reflux disease, dyspepsia, and irritable bowel syndrome: a population-based study.

作者信息

Lee Soon Young, Lee Kwang Jae, Kim Soo Jeong, Cho Sung Won

机构信息

Department of Preventive Medicine and Public Health, Ajou University School of Medicine, Suwon, South Korea.

出版信息

Digestion. 2009;79(3):196-201. doi: 10.1159/000211715. Epub 2009 Apr 3.

DOI:10.1159/000211715
PMID:19342860
Abstract

BACKGROUND/AIMS: People may have symptoms of multiple disorders at the same time. We aimed to determine prevalence and risk factors for overlaps between gastroesophageal reflux disease (GERD), dyspepsia and irritable bowel syndrome (IBS) in a Korean population. METHODS: A cross-sectional survey was performed on 1,688 randomly selected Korean subjects. Data on 1,443 subjects could be analyzed. Dyspepsia and IBS were diagnosed using modified Rome II criteria. RESULTS: The prevalences of GERD, dyspepsia and IBS were 8.5, 9.5 and 9.6%. Overlaps between GERD and dyspepsia, GERD and IBS, and dyspepsia and IBS were observed in 2.3 (95% CI 1.4-3.0), 2.0 (95% CI 1.2-2.6%) and 1.3% (95% CI 0.6-1.8%) of the population. 27 and 24% of GERD subjects suffered from dyspepsia and IBS. 24 and 14% of dyspeptic subjects had GERD and IBS. 21 and 14% of IBS subjects had GERD and dyspepsia. Anxiety was significantly associated with GERD overlap (OR 2.73, 95% CI 1.13-6.57), dyspepsia overlap (OR 3.19, 95% CI 1.33-7.63) and IBS overlap (OR 4.92, 95% CI 2.04-11.84), compared with GERD alone, dyspepsia alone and IBS alone. CONCLUSIONS: Overlaps between GERD, dyspepsia, and IBS are common in the general population. These overlaps occur predominantly in individuals with anxiety.

摘要

背景/目的：人们可能同时出现多种疾病的症状。我们旨在确定韩国人群中胃食管反流病（GERD）、消化不良和肠易激综合征（IBS）重叠的患病率及危险因素。 方法：对1688名随机选取的韩国受试者进行了横断面调查。1443名受试者的数据可进行分析。消化不良和IBS采用改良的罗马II标准进行诊断。 结果：GERD、消化不良和IBS的患病率分别为8.5%、9.5%和9.6%。GERD与消化不良、GERD与IBS以及消化不良与IBS的重叠在人群中的比例分别为2.3%（95%置信区间1.4 - 3.0）、2.0%（95%置信区间1.2 - 2.6%）和1.3%（95%置信区间0.6 - 1.8%）。27%的GERD受试者患有消化不良，24%患有IBS。24%的消化不良受试者患有GERD，14%患有IBS。21%的IBS受试者患有GERD，14%患有消化不良。与单纯GERD、单纯消化不良和单纯IBS相比，焦虑与GERD重叠（比值比2.73，95%置信区间1.13 - 6.57）、消化不良重叠（比值比3.19，95%置信区间1.33 - 7.63）和IBS重叠（比值比4.92，95%置信区间2.04 - 11.84）显著相关。 结论：GERD、消化不良和IBS的重叠在普通人群中很常见。这些重叠主要发生在焦虑个体中。

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Prevalence and risk factors for overlaps between gastroesophageal reflux disease, dyspepsia, and irritable bowel syndrome: a population-based study.

Digestion. 2009

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