Yin J W, Yang Y Q, Xiao S H, Li Y, Jiang H J
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai.
Zhongguo Yao Li Xue Bao. 1991 Sep;12(5):478-80.
Mice infected with 100 and 50 Schistosoma japonicum cercariae for 7 and 35 d respectively were treated with im artemether 100 mg.kg-1.d-1 or arteether 100 and 300 mg.kg-1.d-1 for 2 d. The mice were killed at different intervals within 28 d after medication and the livers were sectioned for histological and histochemical observations. The results showed that both artemether and arteether caused degeneration in the tegument, intestine and genital gland of the hepatic-shifted worms. The glycogen content and alkaline phosphatase (AKP) activity of schistosomula and adult worms decreased 7 d after treatment, especially remarkable in arteether 300 mg.kg-1.d-1 group.
分别用100条和50条日本血吸虫尾蚴感染小鼠7天和35天，然后用蒿甲醚100mg.kg-1.d-1或蒿乙醚100mg.kg-1.d-1和300mg.kg-1.d-1治疗2天。在给药后28天内的不同时间点处死小鼠，取肝脏进行组织学和组织化学观察。结果显示，蒿甲醚和蒿乙醚均引起肝移行虫体的体表、肠和生殖腺发生变性。治疗7天后，童虫和成虫的糖原含量及碱性磷酸酶（AKP）活性降低，尤以蒿乙醚300mg.kg-1.d-1组显著。
