You J, Guo H, Mei J, Jiao P, Feng J, Yao M, Xiao S
Chinese Academy of Preventive Medicine, WHO Collaborating Center for Malaria, Schistosomiasis and Filariasis, Shanghai.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1994;12(4):275-8.
When mice infected with Schistosoma japonicum for 32-35 d were treated ig with artemether (Art) at a single dose of 300 mg.kg-1 for 24 h, the glycogen content of female and male schistosomes decreased significantly with reduction rates of about 50%. 72 h after medication, the glycogen reduction rates were 64.1-77.9%. Meantime, the protein content of female and male worms was also decreased, the reduction rates being 68.1% and 49.3%, respectively. In infected mice treated ig with Art at the same dosage for 24 h, the inhibition rates of alkaline phosphatase (AKP) activity in female and male worms were 30% and 25%, respectively. 72 h later, the AKP activity of female worm was further inhibited to 62.3% as compared with the control. Besides, the inhibitory effect of Art on acid phosphatase (ACP) activity of female worm was also more apparent than that of male worm. 72 h after medication, the respective inhibition rates of ACP activity in female and male worms were 75.7% and 47.6%. The results indicated that Art might exert its effect on both carbohydrate and protein metabolism of schistosomes.
用日本血吸虫感染小鼠32 - 35天后，以300 mg·kg-1的单剂量蒿甲醚（Art）灌胃处理24小时，雌、雄血吸虫的糖原含量显著下降，下降率约为50%。用药72小时后，糖原下降率为64.1% - 77.9%。同时，雌、雄虫体的蛋白质含量也下降，下降率分别为68.1%和49.3%。用相同剂量的蒿甲醚对感染小鼠灌胃处理24小时，雌、雄虫体碱性磷酸酶（AKP）活性的抑制率分别为30%和25%。72小时后，雌虫的AKP活性与对照相比进一步被抑制至62.3%。此外，蒿甲醚对雌虫酸性磷酸酶（ACP）活性的抑制作用也比雄虫更明显。用药72小时后，雌、雄虫体ACP活性的抑制率分别为75.7%和47.6%。结果表明，蒿甲醚可能对血吸虫的碳水化合物和蛋白质代谢均有作用。
