Bogren Anna, Teles Ricardo P, Torresyap Gay, Haffajee Anne D, Socransky Sigmund S, Jönsson Kerstin, Wennström Jan L
Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
J Clin Periodontol. 2008 Feb;35(2):157-64. doi: 10.1111/j.1600-051X.2007.01180.x.
To test the hypothesis of a superior clinical and microbiological effect of the combined use of powered toothbrush+triclosan-containing dentifrice compared with manual toothbrush+regular fluoride-containing dentifrice in periodontal maintenance patients.
A total of 128 periodontitis subjects involved in recall programmes were randomized to use either powered toothbrush with triclosan-dentifrice (test) or manual toothbrush and standard dentifrice (control). Supportive periodontal treatment was provided at baseline and every 6 months. Plaque, bleeding on probing (BoP), probing pocket depth (PPD) and relative attachment level (RAL) were scored at baseline, 1, 2 and 3 years. Subgingival plaque samples were taken and analysed for their content of 40 bacterial species at each examination interval. All analyses were performed by "intention-to-treat" protocol.
Both groups showed significant reduction in BoP, PPD and in mean total counts of the 40 bacterial species between baseline and 3 years, while plaque score and RAL remained almost unchanged. No significant differences between the two prevention programmes were found for any of the clinical outcome variables or in mean counts of the various bacterial species.
The study failed to demonstrate superior clinical and microbiological effects of powered toothbrush+triclosan dentifrice compared with manual toothbrush+standard fluoride-dentifrice in periodontitis-susceptible patients on regular maintenance therapy.
验证在牙周炎维持治疗患者中，与手动牙刷加含常规氟化物牙膏相比，电动牙刷加含三氯生牙膏联合使用在临床和微生物学方面具有更优效果这一假设。
共有128名参与复诊计划的牙周炎患者被随机分为两组，一组使用含三氯生牙膏的电动牙刷（试验组），另一组使用手动牙刷和标准牙膏（对照组）。在基线期及之后每6个月进行一次牙周支持治疗。在基线期、1年、2年和3年时对菌斑、探诊出血（BoP）、探诊袋深度（PPD）和相对附着水平（RAL）进行评分。在每个检查间隔期采集龈下菌斑样本，并分析其中40种细菌的含量。所有分析均按照“意向性分析”方案进行。
两组在基线期至3年期间，BoP、PPD以及40种细菌的平均总数均显著降低，而菌斑评分和RAL几乎保持不变。在任何临床结局变量或各种细菌的平均数量方面，两种预防方案之间均未发现显著差异。
对于接受常规维持治疗的牙周炎易感患者，该研究未能证明电动牙刷加三氯生牙膏与手动牙刷加标准含氟牙膏相比，在临床和微生物学方面具有更优效果。
