遗传背景以及将小鼠研究成果转化至人类研究的困境。
Genetic background and the dilemma of translating mouse studies to humans.
作者信息
Rivera Juan, Tessarollo Lino
机构信息
Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Immunity. 2008 Jan;28(1):1-4. doi: 10.1016/j.immuni.2007.12.008.
PMID:18199409
Abstract
C57BL/6 genetically modified mouse models are the accepted gold standard in biological studies. However, an increasing failure of translating the findings to human (patho)physiology casts doubt on using a single strain to address many questions.
摘要
C57BL/6基因改造小鼠模型是生物学研究中公认的金标准。然而，越来越多将研究结果转化为人类（病理）生理学的失败，让人质疑使用单一品系来解决诸多问题的做法。
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