Harris Tiffany G, Burk Robert D, Yu Herbert, Minkoff Howard, Massad L Stewart, Watts D Heather, Zhong Ye, Gange Stephen, Kaplan Robert C, Anastos Kathryn, Levine Alexandra M, Moxley Michael, Xue Xiaonan, Fazzari Melissa, Palefsky Joel M, Strickler Howard D
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):245-8. doi: 10.1158/1055-9965.EPI-07-0686.
High serum levels of insulin-like growth factor-I (IGF-I) are reported to be a risk factor for several common cancers, and recent cross-sectional data suggest a possible additional association of IGF-I with cervical neoplasia. To prospectively assess whether circulating IGF-I levels influence the natural history of oncogenic human papillomavirus (HPV), the viral cause of cervical cancer, we conducted a pilot investigation of 137 women who underwent semiannual type-specific HPV DNA PCR testing and cervical cytology. Total IGF-I and IGF binding protein-3 (IGFBP-3), the most abundant IGFBP in circulation, were measured using baseline serum specimens. Having a high IGF-I/IGFBP-3 ratio was associated with increased persistence of oncogenic HPV infection [that is, a lower rate of clearance; adjusted hazard ratio (AHR), 0.14; 95% confidence interval (95% CI), 0.04-0.57], whereas IGFBP-3 was inversely associated with both the incident detection of oncogenic HPV (AHR, 0.35; 95% CI, 0.13-0.93) and the incidence of oncogenic HPV-positive cervical neoplasia (that is, squamous intraepithelial lesions at risk of progression; AHR, 0.07; 95% CI, 0.01-0.66). These prospective data provide initial evidence that the IGF axis may influence the natural history of oncogenic HPV.
据报道，高血清胰岛素样生长因子-I（IGF-I）水平是几种常见癌症的危险因素，最近的横断面数据表明IGF-I与宫颈肿瘤可能存在额外关联。为了前瞻性评估循环IGF-I水平是否影响致癌性人乳头瘤病毒（HPV，宫颈癌的病毒病因）的自然病程，我们对137名女性进行了一项初步调查，这些女性每半年接受一次特定类型的HPV DNA PCR检测和宫颈细胞学检查。使用基线血清标本测量总IGF-I和循环中最丰富的IGF结合蛋白-3（IGFBP-3）。IGF-I/IGFBP-3比值高与致癌性HPV感染的持续存在增加相关[即清除率较低；调整后风险比（AHR），0.14；95%置信区间（95%CI），0.04 - 0.57]，而IGFBP-3与致癌性HPV的 incident detection（AHR，0.35；95%CI，0.13 - 0.93）以及致癌性HPV阳性宫颈肿瘤的发生率（即有进展风险的鳞状上皮内病变；AHR，0.07；95%CI，0.01 - 0.66）均呈负相关。这些前瞻性数据提供了初步证据，表明IGF轴可能影响致癌性HPV的自然病程。
原文中“incident detection”可能有误，推测应为“incidence detection”，翻译为“发病检测” 。
