患有败血症的新生儿体内的分泌型磷脂酶A(2)

Secretory phospholipase A(2) in newborn infants with sepsis.

作者信息

Schrama A J J, de Beaufort A J, Poorthuis B J H M, Berger H M, Walther F J

机构信息

Neonatology Unit, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.

出版信息

J Perinatol. 2008 Apr;28(4):291-6. doi: 10.1038/sj.jp.7211929. Epub 2008 Jan 17.

DOI:10.1038/sj.jp.7211929

PMID:18200020

Abstract

OBJECTIVE

To investigate secretory phospholipase A(2) (sPLA(2)) activity in neonatal sepsis.

STUDY DESIGN

Plasma sPLA(2) activity, C-reactive protein (CRP) concentration, leukocyte count and immature/total neutrophil (I/T) ratio were assessed in a group of 156 infants admitted for neonatal intensive care, who were classified as documented sepsis (n=24), suspected infection (n=77) and controls (n=55). Interleukin-6 (IL-6) concentrations were assessed in a subgroup (n=29).

RESULT

sPLA(2) activity, CRP concentration and I/T ratio were higher in sepsis than in suspected infection or control groups. sPLA(2) activity advanced with increasing CRP, I/T ratio and IL-6 was highest in infants with respiratory distress syndrome (RDS). Compared to CRP, sPLA(2) had equal sensitivity and lower specificity. Compared to I/T ratio, sensitivity and specificity of sPLA(2) were higher.

CONCLUSION

Plasma sPLA(2) activity is increased in neonatal sepsis and highest in infants with RDS. Further studies should assess the potential of sPLA(2) inhibition in neonatal sepsis.

摘要

目的

研究新生儿败血症中分泌型磷脂酶A2（sPLA2）的活性。

研究设计

对156名入住新生儿重症监护病房的婴儿进行血浆sPLA2活性、C反应蛋白（CRP）浓度、白细胞计数及未成熟/总中性粒细胞（I/T）比值的评估，这些婴儿被分为确诊败血症组（n = 24）、疑似感染组（n = 77）和对照组（n = 55）。对一个亚组（n = 29）进行白细胞介素-6（IL-6）浓度评估。