Lowes Michelle A, Kikuchi Toyoko, Fuentes-Duculan Judilyn, Cardinale Irma, Zaba Lisa C, Haider Asifa S, Bowman Edward P, Krueger James G
Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York 10021, USA.
J Invest Dermatol. 2008 May;128(5):1207-11. doi: 10.1038/sj.jid.5701213. Epub 2008 Jan 17.
The importance of T helper 17 (Th17) cells in inflammation and autoimmunity is now being appreciated. We analyzed psoriasis skin lesions and peripheral blood for the presence of IL-17-producing T cells. We localized Th17 cells predominantly to the dermis of psoriasis skin lesions, confirmed that IL-17 mRNA increased with disease activity, and demonstrated that IL-17 mRNA expression normalized with cyclosporine therapy. IL-22 mRNA expression mirrored IL-17 and both were downregulated in parallel with keratin 16. Th17 cells are a discrete population, separate from Th1 cells (which are also in psoriasis lesions), and Th2 cells. Our findings suggest that psoriasis is a mixed Th1 and Th17 inflammatory environment. Th17 cells may be proximal regulators of psoriatic skin inflammation, and warrant further attention as therapeutic targets.
辅助性T细胞17（Th17）在炎症和自身免疫中的重要性如今正得到重视。我们分析了银屑病皮肤病变组织和外周血中产生白细胞介素-17（IL-17）的T细胞。我们发现Th17细胞主要定位于银屑病皮肤病变的真皮层，证实IL-17信使核糖核酸（mRNA）随疾病活动度增加，并且表明环孢素治疗后IL-17 mRNA表达恢复正常。IL-22 mRNA表达与IL-17一致，二者均与角蛋白16平行下调。Th17细胞是一个独立的细胞群体，与Th1细胞（也存在于银屑病病变中）和Th2细胞不同。我们的研究结果表明，银屑病是一个Th1和Th17混合的炎症环境。Th17细胞可能是银屑病皮肤炎症的近端调节因子，作为治疗靶点值得进一步关注。
