Fischer U, Zeitschel U, Jakubke H D
Leipzig University, Department of Biochemistry, Germany.
Biomed Biochim Acta. 1991;50(10-11):S131-5.
Peptide synthesis with chymotrypsin in organic solvents was investigated and the apparent partition constants have been measured. We find that the Papp values of the most amino acids and peptide derivatives are drastically changed and the stereo- and regiospecificity in acetonitrile/water mixture is reduced.
研究了在有机溶剂中用胰凝乳蛋白酶进行肽合成，并测定了表观分配常数。我们发现，大多数氨基酸和肽衍生物的Papp值发生了显著变化，且在乙腈/水混合物中的立体和区域特异性降低。
