Buschgens C J M, van Aken M A G, Swinkels S H N, Altink M E, Fliers E A, Rommelse N N J, Minderaa R B, Sergeant J A, Faraone S V, Buitelaar J K
Department of Child and Adolescent Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
J Neural Transm (Vienna). 2008;115(2):177-86. doi: 10.1007/s00702-007-0838-x. Epub 2008 Jan 16.
Behavioral genetic studies imply that salient environmental influences operate within families, making siblings in a family different rather than similar. This study is the first one to examine differential sibling experiences (as measured with the Sibling Inventory of Differential Experience) and its effect on behavioral outcomes within ADHD families. Subjects were 45 Dutch ADHD probands and their unaffected siblings (n = 45) aged 10-18 years. ADHD probands and their unaffected siblings reported differences in sibling interaction, parental treatment, and peer characteristics. These nonshared environmental influences were related to both the severity of ADHD symptoms as well as to comorbid problem behaviors. These findings suggest that environmental influences that operate within ADHD families appear relevant to the severity of problem behaviors of ADHD children and their siblings.
行为遗传学研究表明，显著的环境影响在家庭中起作用，使得家庭中的兄弟姐妹彼此不同而非相似。本研究首次考察了差异化的手足经历（用差异化经历手足量表来衡量）及其对多动症家庭中行为结果的影响。研究对象为45名荷兰多动症先证者及其10至18岁未受影响的手足（n = 45）。多动症先证者及其未受影响的手足报告了在手足互动、父母对待方式和同伴特征方面的差异。这些非共享环境影响与多动症症状的严重程度以及共病问题行为均有关联。这些发现表明，多动症家庭中起作用的环境影响似乎与多动症儿童及其手足问题行为的严重程度相关。
