Tudorache B, Diacicov S
Institute of Neurology and Psychiatry, Bucharest, Romania.
Rom J Neurol Psychiatry. 1991 Jul-Dec;29(3-4):209-13.
Twenty hospitalized patients have been treated for acute mania with doses of 450-750 micrograms/day of clonidine (an alpha 2-adrenergic agonist), for one month. The tolerance to the given doses was excellent. A marked decrease of the manic symptoms was noted in 65% of the patients during the first 10 days of the treatment. The response was prompt and maintained for the whole period of the research, the clonidine being efficient on the whole scale of the manic syndrome. The sedating effect was much lower than in the case of neuroleptics; it is quite likely that the clonidine could represent an advance in the acute treatment of manic patients.
20名住院患者接受了可乐定（一种α2-肾上腺素能激动剂）治疗急性躁狂症，剂量为每日450 - 750微克，为期一个月。对给定剂量的耐受性良好。在治疗的前10天，65%的患者躁狂症状明显减轻。反应迅速且在整个研究期间持续存在，可乐定对整个躁狂综合征都有效。其镇静作用远低于抗精神病药物；很有可能可乐定在躁狂症患者的急性治疗中代表了一种进步。
