Hardy M C, Lecrubier Y, Widlöcher D
Am J Psychiatry. 1986 Nov;143(11):1450-3. doi: 10.1176/ajp.143.11.1450.
The authors treated 24 newly hospitalized patients suffering from acute mania with 450-900 micrograms/day of clonidine, an alpha 2-adrenergic agonist, for 2 weeks. A marked decrease in manic symptoms was observed after 5 and 13 days of treatment in about half of the patients. Early response seemed to predict the final result. Patients with a family history of affective disorder and patients who had had a good response to neuroleptics during a previous manic episode tended not to respond to clonidine. At the doses given, the patients' tolerance to clonidine was excellent: sedation was markedly lower than it is with neuroleptic treatment.
作者用α2肾上腺素能激动剂可乐定，以每日450 - 900微克的剂量，对24名新入院的急性躁狂症患者进行了为期2周的治疗。治疗5天和13天后，约半数患者的躁狂症状明显减轻。早期反应似乎可预测最终疗效。有情感障碍家族史的患者以及在前一次躁狂发作期间对抗精神病药物反应良好的患者，往往对可乐定无反应。在给定剂量下，患者对可乐定的耐受性良好：镇静作用明显低于使用抗精神病药物治疗时。
