Al-Salam Suhail, Nowotny Norbert, Sohail Mohammed Rizwan, Kolodziejek Jolanta, Berger Thomas G
Department of Pathology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
J Cutan Pathol. 2008 Jun;35(6):603-7. doi: 10.1111/j.1600-0560.2007.00857.x. Epub 2008 Jan 14.
Ecthyma contagiosum (orf) is caused by an epitheliotropic parapox virus. It is a zoonosis usually transmitted to humans from affected sheep or goat through direct contact or contaminated fomites.
We report a 36-year-old patient with multiple skin lesions on his left hand, first observed 5 days before admission followed by red streaks on the forearm and an erythema on the upper arm 1 day prior to admission. The patient reported that he was working on a sheep farm.
Histopathologic examination showed evidence of a viral infection. Subsequent transmission electron microscopy showed typical parapox virus particles, predominantly in the scaled-off layers of degenerated keratinocytes and monocytes. The results were verified and specified by two newly established polymerase chain reaction (PCR) assays and subsequent sequencing of the amplicons: one broadly reacting 'general parapox virus PCR', and one assay which allows--following sequencing--discrimination between individual orf virus strains.
Despite the multiplicity of the lesions, there was a significant improvement after 2 weeks of treatment. Sequencing showed the uniqueness of this virus compared with previously published strains from other countries.
传染性脓疱病（羊痘疮）由嗜上皮性副痘病毒引起。它是一种人畜共患病，通常通过直接接触或被污染的污染物从受感染的绵羊或山羊传播给人类。
我们报告一名36岁男性患者，左手出现多处皮肤病变，入院前5天首次发现，入院前1天前臂出现红色条纹，上臂出现红斑。患者报告称他在一个养羊场工作。
组织病理学检查显示有病毒感染迹象。随后的透射电子显微镜检查显示典型的副痘病毒颗粒，主要存在于退化角质形成细胞和单核细胞的鳞屑层中。通过两种新建立的聚合酶链反应（PCR）检测及随后对扩增产物的测序对结果进行了验证和明确：一种是广泛反应的“通用副痘病毒PCR”，另一种检测方法在测序后可区分不同的羊痘疮病毒株。
尽管病变多样，但经过2周治疗后有显著改善。测序显示该病毒与其他国家先前发表的毒株相比具有独特性。
