Sakuma K, Kano Y, Fukuhara M, Shiohara T
Department of Dermatology, Kyorin University School of Medicine, Shinkawa Mitaka, Tokyo, Japan.
Clin Exp Dermatol. 2008 May;33(3):287-90. doi: 10.1111/j.1365-2230.2007.02645.x. Epub 2008 Jan 14.
Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) is a severe multiorgan reaction with reactivation of herpesviruses. Various features are often seen during the course of the disease. Many aspects of this syndrome suggest close similarities between DIHS/DRESS and graft-versus-host disease. We describe a patient with phenobarbital-induced hypersensitivity syndrome who revealed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with limbic encephalitis during the course of the disease. In view of previous reports that SIADH and limbic encephalitis are caused by reactivation of latent herpesviruses after transplantation, both conditions may be secondarily caused by reactivation of latent herpesviruses, which is typically observed in DIHS/DRESS. These neurological symptoms should be added to a growing list of important complications of DIHS/DRESS because of the high mortality rate associated with them.
药物性超敏反应综合征（DIHS）/伴嗜酸性粒细胞增多和全身症状的药物疹（DRESS）是一种伴有疱疹病毒再激活的严重多器官反应。在疾病过程中常可见到各种特征。该综合征的许多方面表明DIHS/DRESS与移植物抗宿主病之间有密切相似性。我们描述了一名苯巴比妥诱发的超敏反应综合征患者，其在疾病过程中出现了与边缘性脑炎相关的抗利尿激素不适当分泌综合征（SIADH）。鉴于先前有报道称SIADH和边缘性脑炎是移植后潜伏疱疹病毒再激活所致，这两种情况可能继发于潜伏疱疹病毒的再激活，这在DIHS/DRESS中较为常见。由于与之相关的高死亡率，这些神经症状应被列入DIHS/DRESS越来越多的重要并发症之中。
