Ozisik Lale, Tanriover Mine Durusu, Saka Esen
Department of Internal Medicine, Hacettepe University Faculty of Medicine, Turkey.
Intern Med. 2016;55(10):1393-6. doi: 10.2169/internalmedicine.55.6035. Epub 2016 May 15.
Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe drug hypersensitivity reaction characterized by rash, fever and multi-organ failure. Limbic encephalitis (LE) is a rare disorder characterized by cognitive dysfunction with memory disturbance, seizures and psychiatric symptoms. We herein present an unusual case of DRESS syndrome due to lamotrigine with reactivation of Epstein-Barr virus, which developed autoimmune LE and syndrome of inappropriate antidiuretic hormone secretion. Discontinuation of lamotrigine, administration of methylprednisolone and intravenous immunoglobulin led to improvement. The LE in this case might have been caused by an autoimmune inflammatory mechanism associated with DRESS syndrome.
药物疹伴嗜酸性粒细胞增多和全身症状（DRESS）是一种严重的药物超敏反应，其特征为皮疹、发热和多器官功能衰竭。边缘叶脑炎（LE）是一种罕见疾病，其特征为伴有记忆障碍的认知功能障碍、癫痫发作和精神症状。我们在此报告一例因拉莫三嗪导致的DRESS综合征罕见病例，该病例伴有EB病毒再激活，并发展为自身免疫性LE和抗利尿激素分泌不当综合征。停用拉莫三嗪、给予甲泼尼龙和静脉注射免疫球蛋白后病情有所改善。该病例中的LE可能是由与DRESS综合征相关的自身免疫性炎症机制引起的。
