Poonawalla T, Colome-Grimmer M I, Kelly B
Department of Internal Medicine, University of Texas Medical Branch, Texas, USA.
Clin Exp Dermatol. 2008 May;33(3):282-6. doi: 10.1111/j.1365-2230.2007.02643.x. Epub 2008 Jan 14.
We present a case of a patient with pulmonary sarcoidosis who developed ulcerative sarcoidosis with granulomatous vasculitis on the lower legs. Ulceration is a rare presentation for sarcoidosis and this case gives further evidence that an underlying vasculitis may be an aetiological factor. Granulomatous vasculitis, classically associated with Wegener's granulomatosis, lymphomatoid granulomatosis, or Churg-Strauss syndrome, is also commonly described in pulmonary sarcoidosis. It has, however, only rarely been described in cutaneous sarcoidosis. Our patient's leg ulcers have responded well to immunosuppressive therapy with tapered corticosteroid and low-dose azathioprine.
我们报告一例肺结节病患者，其双下肢出现溃疡性结节病并伴有肉芽肿性血管炎。溃疡是结节病的一种罕见表现，该病例进一步证明潜在的血管炎可能是一个病因学因素。肉芽肿性血管炎，传统上与韦格纳肉芽肿、淋巴瘤样肉芽肿或变应性肉芽肿性血管炎相关，在肺结节病中也很常见。然而，它在皮肤结节病中很少被描述。我们患者的腿部溃疡对逐渐减量的皮质类固醇和低剂量硫唑嘌呤的免疫抑制治疗反应良好。
