一个用于基因搭便车的精确模型。
An accurate model for genetic hitchhiking.
作者信息
Eriksson Anders, Fernström Pontus, Mehlig Bernhard, Sagitov Serik
机构信息
Department of Energy and Environment, Chalmers University of Technology, Göteborg, Sweden.
出版信息
Genetics. 2008 Jan;178(1):439-51. doi: 10.1534/genetics.107.076018.
We suggest a simple deterministic approximation for the growth of the favored-allele frequency during a selective sweep. Using this approximation we introduce an accurate model for genetic hitchhiking. Only when Ns<10 (N is the population size and s denotes the selection coefficient) are discrepancies between our approximation and direct numerical simulations of a Moran model notable. Our model describes the gene genealogies of a contiguous segment of neutral loci close to the selected one, and it does not assume that the selective sweep happens instantaneously. This enables us to compute SNP distributions on the neutral segment without bias.
我们针对选择性清除过程中有利等位基因频率的增长提出了一种简单的确定性近似方法。利用这种近似方法，我们引入了一个精确的遗传搭便车模型。只有当Ns<10（N为种群大小，s表示选择系数）时，我们的近似方法与莫兰模型的直接数值模拟之间的差异才会显著。我们的模型描述了靠近被选择位点的一段连续中性位点的基因谱系，并且不假设选择性清除瞬间发生。这使我们能够无偏差地计算中性片段上的单核苷酸多态性（SNP）分布。
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