Xie J F
School of Stomatology, Beijing Medical University.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1991 Nov;26(6):336-8, 388.
The purpose of this paper is to observe the blocking effect of topically subepithelial injected drug and Vit A acid painting on chemically induced oral precancerous lesion and to prove, on a certain extent, the hypothesis that subepithelial connective tissue could exert great influence on the differentiation of the epithelium. A total of 49 syrian hamster was used as experimental animal. Both buccal pouches of all animals were painted thrice weekly with 0.5% DMBA in acetone for 6 weeks. Then, they were divided into two groups: Control group and Experimental group. In the latter group, 70.8% precancerous lesions turned into normal epithelial tissue, whereas those untreated animals developed carcinoma by 62%.
本文的目的是观察上皮下局部注射药物和涂抹维甲酸对化学诱导的口腔癌前病变的阻断作用，并在一定程度上证明上皮下结缔组织可能对上皮细胞分化产生重大影响这一假说。总共49只叙利亚仓鼠被用作实验动物。所有动物的双侧颊囊每周用丙酮中的0.5%二甲基苯并蒽涂抹三次，持续6周。然后，将它们分为两组：对照组和实验组。在后一组中，70.8%的癌前病变转变为正常上皮组织，而那些未治疗的动物62%发生了癌变。
