Xie J F
Zhonghua Kou Qiang Yi Xue Za Zhi. 1989 May;24(3):149-51, 191.
The establishment of a model to study the development of oral precancerous lesion is described. 13 samples of DMBA induced hamster cheek pouch precancerous lesions were transplanted to subcutaneous sites in the flank region of nude mice. The transplants were recovered after 14 days and 28 days with a successful recovery rate of 61.9%. The histologic epithelial features of the transplants were compared with those of the original precancerous lesions. Four transplants from 5 mild dysplasia still keep their original histologic epithelial features, and one returns to normal. There are two transplants from 4 simple hyperplasia develop to moderate dysplasia, and one moderate dysplasia changed into mild dysplasia. The experimental result provides good evidence that it is possible to use nude mice to observe the development of various precancerous lesion, especially dysplasia.
本文描述了一种用于研究口腔癌前病变发展的模型的建立。将13个二甲基苯并蒽诱导的仓鼠颊囊癌前病变样本移植到裸鼠侧腹区域的皮下部位。14天和28天后取出移植物，成功回收率为61.9%。将移植物的组织学上皮特征与原始癌前病变的特征进行比较。5个轻度发育异常样本中的4个移植物仍保持其原始组织学上皮特征，1个恢复正常。4个单纯增生样本中的2个移植物发展为中度发育异常，1个中度发育异常转变为轻度发育异常。实验结果提供了有力证据，表明利用裸鼠观察各种癌前病变尤其是发育异常的发展是可行的。
