Xie J F
Zhonghua Kou Qiang Yi Xue Za Zhi. 1989 Jul;24(4):224-7, 255.
The purpose of this study is to observe the blocking effect of topically subepithelial injected drug on chemically induced oral precancerous lesion and to prove, on a certain extent, the hypothesis that subepithelial connective tissue could exert great influence on the differentiation of the epithelium. A total of 97 syrian hamster was used as experimental animal. Both buccal pouches of all animals were painted thrice weekly with 0.5% DMBA in acetone for 6 weeks. They were divided into two groups: control group and blocking group. In those animals which received topical injected thioproline for 6 weeks, 45.5% precancerous lesions turned into normal epithelial tissue, whereas those untreated animals developed carcinoma by 100%. The result of experimental study supports the hypothesis that the eventual fate of premalignant epithelium may be determined by effect that the underlying connective tissue is able to exert on it.
本研究的目的是观察上皮下局部注射药物对化学诱导的口腔癌前病变的阻断作用，并在一定程度上证明上皮下结缔组织可能对上皮细胞分化产生重大影响这一假设。总共97只叙利亚仓鼠被用作实验动物。所有动物的双侧颊囊每周用0.5%二甲基苯蒽丙酮溶液涂抹三次，持续6周。它们被分为两组：对照组和阻断组。在那些接受局部注射硫代脯氨酸6周的动物中，45.5%的癌前病变转变为正常上皮组织，而那些未治疗的动物100%发生了癌变。实验研究结果支持这样的假设，即癌前上皮的最终命运可能由其下方结缔组织对其产生的影响所决定。
